马克% % 0期刊文章%内格尔,Suggett, Jason %A Kushnarev, Vladimir %A Coppolo, Dominic %A Wesolowski, Anthony %A Corcoran, Timothy %T Combining Inhalation by A Breath Actuated Nebuliser (BAN) With Exhalation Through An Oscillating Positive Expiratory Pressure Device (OPEP) Offers The Potential For Optimal Combined Therapy %D 2019 %R 10.1183/13993003.congress-2019.PA4529 %J European Respiratory Journal %P PA4529 %V 54 %N suppl 63 %X Rationale: OPEP therapy when combined with nebulised drug delivery or hypertonic saline offers the potential to reduce combined treatment time. Aerosol deposition scintigraphy was undertaken to assess in vivo pulmonary deposition from a BAN (AEROECLIPSE* II) coupled to an OPEP device (Aerobika*) compared to deposition from the nebuliser alone.Methods: Eight healthy subjects received albuterol (2.5 mg/3mL) admixed with 2 mCi of Tc-DTPA (Technetium-99m bound to diethylenetriaminepentaacetic acid) administered using the BAN alone and again when the BAN was combined with the OPEP device. Regional doses were then determined from anterior and posterior gamma camera images collected after delivery. Lung perimeters were defined using Cobalt-57 transmission scans and applied to Tc-DTPA deposition images. Results were expressed as a percentage of baseline counts.Results: Average age of all 8 subjects (4 male, 4 female) was 33 years. Whole lung deposition was, on average, 31±13 vs 32±13% of loaded dose for BAN alone and BAN+OPEP respectively.Conclusions: The delivery of medication from the AEROECLIPSE* II BAN to the lungs was not significantly affected by the incorporation of the Aerobika* OPEP device. This therapy could offer the clinician the opportunity for combined aerosol/OPEP therapy (ie in cystic fibrosis patients) thereby reducing the time needed for the patient to take nebuliser and OPEP treatment separately.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4529.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). %U