摘要
我们研究了鼻病毒(RV)感染对呼吸道反应性的影响。27例正常志愿者(11例特应性患者)接种rv2或RV EL。在接种前、接种后7天和21天测定了在1秒钟内产生15%的强制呼气量下降(FEV1) (PC15FEV1)所需的组胺和缓激肽的激发浓度。通过四倍的抗病毒抗体滴度和鼻腔冲洗的病毒培养来确定感染。呼气峰流速(PEF)记录前三天,接种后21天。所有受试者都接受了前两次支气管挑战,22人接受了第三次挑战。在整个组和特应性受试者中,缓激肽和组胺的PC15值之间存在显著相关性(r = 0.82和0.85)。20名受试者被感染;6人患了临床感冒。16个感染的受试者有所有三种挑战,组胺挑战的中位(范围)PC15FEV1是36(0.89-64),62(1.5-64)和34 (0.94-64)mg。分别为ml-1和32mg。ml-1 for each bradykinin challenge (range: 0.015-32, 0.088-32 and 0.033-32). There were no significant differences between study days for PC15FEV1 histamine or bradykinin for the whole group, the infected subjects, those with clinical colds or for those infected with either RV subtype. There was no significant change in mean daily PEF after viral infection. We conclude that airways reactivity to histamine and bradykinin is unchanged after experimental RV infection in normal volunteers.