Ty-jour t1 - 与组胺和bradykinin的支气管反应性在正常主题中rhinovirus感染后没有变化，JF - 欧洲呼吸期刊Jo - Eur Respir J SP - 313 LP - 317 VL - 5是 - 3 Au - 夏天，QA Au - Higgins，PG AU - Barrow，Ig Au - Tyrrell，Da Au - Holgate，St Y1 - 1992/03/01 UR - //www.qdcxjkg.com/content/5/3/313.abstract n2 - 我们调查了这一效果鼻病毒（RV）感染气道反应性。用RV 2或RV EL接种二十七种正常志愿者（11个Atopic）。在接种后7和21天之前，测量生成15％所需的组胺和Bradykin所需的组胺和Bradykin的诱惑浓度在一个第二（FEV1）（PC15Fev1）中。通过抗病毒抗体滴注的四倍升高和来自鼻腔洗涤的病毒培养来确定感染。在接种后3天和21天进行峰值呼气流速（PEF）。所有受试者都经历了前两个支气管挑战，以及22次第三次挑战。对于整个组和特应性受试者，Bradykinin和组胺的PC15值与分别存在显着的相关性（分别为r = 0.82和r = 0.85）。20个受试者被感染; six had clinical colds. For the 16 infected subjects who had all three challenges, the median (range) PC15FEV1 for the histamine challenges was 36 (0.89-64), 62 (1.5-64) and 34 (0.94-64) mg.ml-1, respectively, and 32 mg.ml-1 for each bradykinin challenge (range: 0.015-32, 0.088-32 and 0.033-32). There were no significant differences between study days for PC15FEV1 histamine or bradykinin for the whole group, the infected subjects, those with clinical colds or for those infected with either RV subtype. There was no significant change in mean daily PEF after viral infection. We conclude that airways reactivity to histamine and bradykinin is unchanged after experimental RV infection in normal volunteers. ER -