抽象的
我们测试了假设,即中断脊髓向呼吸肌动机的电动机交通中断抑制了对化学驱动量增加的通气反应。我们将缺氧(HVR)和高型(HCVR)的逆型(HCVR)逆变反应进行比较,在17例高宫颈脊髓横断调和17例正常受试者中的17例四肢患者中的吸气式流动载荷之前和期间。从微小通风(VE)和口腔闭塞压力(P0.2)对动脉氧饱和度(SAO2)或末端潮汐PCO2(PACO2)的斜坡评估通气反应,以及SaO 2 80%或Paco2的绝对Ve值55 mmhg。我们发现在二次互联网和正常科目之间的卸载的HVR或HCVR中没有发现。在加载的HVR中,Delta Ve / Delta SaO2斜率在两组受试者中倾向于同样地降低。Delta p0.2 / delta sao2斜率在正常受试者上向上移动,在给定的Sao2处产生显着更高的p0.2。相比之下,在二次互联网中不存在于加载HVR期间P0.2水平的这种升高。载荷的HCVR在两组受试者中产生定性相似;Delta VE / Delta Paco2减少,Delta P0.2 / Delta Paco2显着增加。 The results show that the ventilatory chemosensory responses were unsuppressed in quadriplegics, although they displayed a disturbance in load-compensation, as reflected by occlusion pressure, in hypoxia. We conclude that the descending drive to respiratory muscle motoneurons is not germane to the operation of the chemosensory reflexes.