抽象
上呼吸道可有助于在通过乙酰甲胆碱(MCH)诱发的呼吸阻力的增加。本研究的目的是要同时评估上气道的MCH响应和下呼吸道阻力(RUA,RRS,LO)和电抗(随感,Xrs的,LO),并测试是否呼吸总电阻和电抗的变化后MCH通过上呼吸道的机制受到影响。七只猫自主呼吸下进行氯醛,氨基甲酸乙酯麻醉的研究。由连接到咽腔一个扩音以20Hz产生强制振动。呼吸速度描放置被切断的颈气管的喙和尾部末端之间。压降越过上气道和整个下呼吸系统测量。街,随感,RRS,LO与Xrs,雾化生理盐水后获得Io和MCH直接通过气管造口给药。分析集中于MCH测试结果,显示明显的正上气道的反应。RRS,LO和街的体积和流动依赖使用多元线性回归分析潮汐吸气期间进行了评估。 After Mch, Rrs,lo increased and became negatively volume dependent, while the increase in Rua was associated with no significant change in volume dependence; Xrs,lo became negative while Xua did not change. The upper airways response to methacholine may thus contribute to the increase in total respiratory resistance but may not account for either its negative volume dependence or the decrease in total resistance. It is surmised that these features more specifically reflect alterations in respiratory mechanics occurring at the level of the intrathoracic airways.