抽象的
已经研究了98名吸烟者横截面的支气管反应性(CBR)。所有参与者都受到普通过敏原,肺功能测量和支气管挑战与甲素和香烟烟雾的影响。在第一次卷烟挑战之后,38名参与者在1小时内进行了1小时的重新检查。分析的肺功能指数是:强制呼气量在一秒钟内(FEV1);最大呼气流量为5%的强制生命能力(MEF75%);并强迫中期流动在强制生命能力的25%至75%(FEF(25-75%)之间。所有参与者都经过哮喘和过敏,所以需要提供有关呼吸系统症状的信息,第一学位亲属,具有哮喘和过敏习惯和吸烟习惯。在12卷烟吸入后的所有肺功能指数中,只有FEV1与其他变量有关,但在其他变量中只能看到大量减少。FEV1的最大平均百分比均为10%,与吸入数直接相关(P <0.05)。在多元回归中,FEV1的百分比下降与:FEV1 /重要容量(VC)(P <0.01); to the asthmatic/bronchitic status (p<0.05); and to the accumulated and standardized cigarette consumption (p<0.05). The percentage fall in FEV1 bore no relationship to methacholine bronchial reactivity, sex or age and had a continuous distribution. The repeat challenge showed a smaller fall in FEV1 compared to the first challenge after 12 cigarette smoke inhalations (p<0.05). The percentage fall in FEV1 correlated after the first and the repeat challenge (p<0.05). Repeatability of the challenge could not be determined in this study because of tachyphylaxis. Bronchial reactivity to cigarette smoke is a tobacco smoke-specific bronchial response. All participants responded and the response showed a continuous distribution. Bronchial reactivity to cigarette smoke may be of importance for symptoms and prognosis in chronic bronchitis and chronic obstructive pulmonary disease and should be studied in relation to the degree of accelerated lung function loss in smokers and other cigarette induced lung abnormalities.