TY - JOUR T1 -吸烟者对香烟的支气管反应:JF - European Respiratory Journal JO - Eur Respir J SP - 670 LP - 676 VL - 11 IS - 3 AU - Jensen, EJ AU - Dahl, R AU - Steffensen，在98名吸烟者的横截面上研究了N2 -支气管对香烟烟雾(CBR)的反应性。所有参与者都接受了常见过敏原的皮肤点刺试验、肺功能测量以及对甲基胆碱和香烟烟雾的支气管刺激。38名参与者在第一次吸烟1小时后再次接受香烟挑战。肺功能指标分析:1秒用力呼气量(FEV1);最大呼气流量75%的强迫肺活量(MEF75%);强迫呼气中流量为强迫肺活量的25-75% (FEF(25-75%))。所有参与者都接受了哮喘和过敏测试，并被要求提供有关呼吸道症状、患有哮喘和过敏的一级亲属以及吸烟习惯的信息。12次吸卷烟后，各肺功能指标均显著下降，但仅FEV1与其他指标相关。 The maximal mean percentage fall in FEV1 was 10%, which was directly related to the number of inhalations (p<0.05). In multiple regression analyses the percentage fall in FEV1 was directly related to: FEV1/vital capacity (VC) (p<0.01); to the asthmatic/bronchitic status (p<0.05); and to the accumulated and standardized cigarette consumption (p<0.05). The percentage fall in FEV1 bore no relationship to methacholine bronchial reactivity, sex or age and had a continuous distribution. The repeat challenge showed a smaller fall in FEV1 compared to the first challenge after 12 cigarette smoke inhalations (p<0.05). The percentage fall in FEV1 correlated after the first and the repeat challenge (p<0.05). Repeatability of the challenge could not be determined in this study because of tachyphylaxis. Bronchial reactivity to cigarette smoke is a tobacco smoke-specific bronchial response. All participants responded and the response showed a continuous distribution. Bronchial reactivity to cigarette smoke may be of importance for symptoms and prognosis in chronic bronchitis and chronic obstructive pulmonary disease and should be studied in relation to the degree of accelerated lung function loss in smokers and other cigarette induced lung abnormalities. ER -