抽象
哮喘患者存在肺气肿的证据是有争议的。我们之前已经表明,通过计算断层(CT)扫描测量的肺部密度降低,术前与随后切除肺部的微观肺气肿的形态测量进行相关。本研究的目的是将CT肺密度进行比较,17例慢性哮喘患者(强迫呼气量在一秒(FEV1)1.98(SD 0.77)L),17例慢性支气管炎患者和肺气肿(FEV1 0.97(0.56))和七个正常对象(FEV1 3.5(034)L)。所有受试者在彼此的2天内接受CT扫描和呼吸功能测试。在哮喘患者中的五个中,在用雾化支气管扩张剂处理之前和之后两次进行CT扫描。在不同组的五个哮喘中,这些测量在加剧后在和6周结束时进行。慢性阻塞性肺病(COPD)患者的最低第五百分位数的平均值为-942(SD 36)Hounsfield单位(Hu),在17例哮喘患者中为-912(34)胡,在正常的科目中是-880(13)。Despite a significant increase in peak expiratory flow rate from 266 (SD 102) to 406 (83) L x s(-1) (p<0.02) following nebulized beta2-agonist in five patients with chronic asthma, there was no significant change in CT lung density (p>0.05) Our study indicates that at least some patients with chronic, stable asthma develop a reduction in computed tomography lung density, similar to that in patients with emphysema.