Extract
Judicious points are raised in correspondence by J. Messika and co-workers, as well as in the editorial by Glanville[1] accompanying our prior work regarding “SuccessfulPseudomonas aeruginosaeradication improves outcomes after lung transplantation: a retrospective cohort analysis” [2]. Briefly, our study assessed the outcomes of a therapeutic approach to prospectively eradicatePseudomonas aeruginosafrom the respiratory tract in lung transplant recipients, using a susceptibility-directed targeted antibiotic treatment policy as of September 2011. We performed segmented time-based outcome analysis, investigating subsequent chronic lung allograft dysfunction (CLAD) development and graft survival. As hypothesised, based on the extensively documented detrimental effects ofPseudomonas aeruginosain other respiratory disorders [3] and after lung transplantation [4–6], improved CLAD-free and graft survival, as well as better preserved pulmonary function over time, were seen in lung transplant recipients in whomPseudomonas aeruginosawas successfully eradicated (n=76)versusthose with persistent respiratory culture-positivity (n=19).
Abstract
Respiratory tract colonisation withPseudomonas aeruginosamay represent a treatable trait to avert subsequent development of chronic lung allograft dysfunction in lung transplant recipientshttps://bit.ly/35rCVhW
Footnotes
Author contributions: R. Vos: wrote the manuscript; A. Van Herck: critically revised the manuscript.
Conflict of interest: R. Vos reports grants from Research Foundation-Flanders (FWO), outside the submitted work.
Conflict of interest: A. Van Herck has nothing to disclose.
支持声明:r . Vos高级临床research fellow of the Fund for Scientific Research Flanders (FWO). Funding information for this article has been deposited with theCrossref Funder Registry.
- ReceivedJanuary 7, 2021.
- AcceptedJune 9, 2021.
- Copyright ©The authors 2021. For reproduction rights and permissions contactpermissions{at}ersnet.org