TY -的T1 - < em >绿脓杆菌< / em >chronic lung allograft dysfunction: does evading an iceberg prevent the ship from sinking? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00041-2021 VL - 58 IS - 1 SP - 2100041 AU - Vos, Robin AU - Van Herck, Anke Y1 - 2021/07/01 UR - //www.qdcxjkg.com/content/58/1/2100041.abstract N2 - Judicious points are raised in correspondence by J. Messika and co-workers, as well as in the editorial by Glanville [1] accompanying our prior work regarding “Successful Pseudomonas aeruginosa eradication improves outcomes after lung transplantation: a retrospective cohort analysis” [2]. Briefly, our study assessed the outcomes of a therapeutic approach to prospectively eradicate Pseudomonas aeruginosa from the respiratory tract in lung transplant recipients, using a susceptibility-directed targeted antibiotic treatment policy as of September 2011. We performed segmented time-based outcome analysis, investigating subsequent chronic lung allograft dysfunction (CLAD) development and graft survival. As hypothesised, based on the extensively documented detrimental effects of Pseudomonas aeruginosa in other respiratory disorders [3] and after lung transplantation [4–6], improved CLAD-free and graft survival, as well as better preserved pulmonary function over time, were seen in lung transplant recipients in whom Pseudomonas aeruginosa was successfully eradicated (n=76) versus those with persistent respiratory culture-positivity (n=19).Respiratory tract colonisation with Pseudomonas aeruginosa may represent a treatable trait to avert subsequent development of chronic lung allograft dysfunction in lung transplant recipients https://bit.ly/35rCVhW ER -