Extract
We read with interest the research letter published by DaviesF奥斯曼et al. [1] in theEuropean Respiratory Journal. The authors determined the proportion of multidrug-resistant tuberculosis patients treated with moxifloxacin or levofloxacin who attained an optimal exposure for these drugs. The target exposure corresponded to the area under the curve (AUC0–24h)/minimal inhibitory concentration (MIC) ratio generating the optimal bactericidal activity. The authors based their calculations on the AUC0–24h/MIC ratio measured in a preclinical model called Hollow Fiber System (HFS), anin vitro用于评估候选药物抗结核活性的模型。基于该模型,他们报告说,仅接受莫西沙星的患者中只有一半的患者达到了目标比,而在接受左氧氟沙星的患者中也达到了目标比。
抽象的
The proportion of TB patients attaining the fluoroquinolone target exposure, as defined byin vitromodels, is very low in clinical practice; however, it would be even smaller if the target AUC/MIC ratios were calculated in murine models of tuberculosishttps://bit.ly/2Wg8K8H
脚注
利益冲突:T。Maitre无话可说。
利益冲突:L。Guglielmetti无话可说。
Conflict of interest: N. Veziris reports grants from Bioversys and Janssen, personal fees from Insmed, outside the submitted work.
- 已收到November 24, 2020.
- AcceptedDecember 4, 2020.
- 复制right ©ERS 2021