Extract
We read with interest the research letter published by Davies Forsman et al. [1] in the European Respiratory Journal. The authors determined the proportion of multidrug-resistant tuberculosis patients treated with moxifloxacin or levofloxacin who attained an optimal exposure for these drugs. The target exposure corresponded to the area under the curve (AUC0–24h)/minimal inhibitory concentration (MIC) ratio generating the optimal bactericidal activity. The authors based their calculations on the AUC0–24h/MIC ratio measured in a preclinical model called Hollow Fiber System (HFS), an in vitro model used to assess anti-tuberculosis activity of candidate drugs. Based on this model, they reported that the target ratio was reached in only half of patients receiving moxifloxacin, and in none of those receiving levofloxacin.
Abstract
The proportion of TB patients attaining the fluoroquinolone target exposure, as defined by in vitro models, is very low in clinical practice; however, it would be even smaller if the target AUC/MIC ratios were calculated in murine models of tuberculosis https://bit.ly/2Wg8K8H
Footnotes
Conflict of interest: T. Maitre has nothing to disclose.
Conflict of interest: L. Guglielmetti has nothing to disclose.
Conflict of interest: N. Veziris reports grants from Bioversys and Janssen, personal fees from Insmed, outside the submitted work.
- Received November 24, 2020.
- Accepted December 4, 2020.
- Copyright ©ERS 2021