Extract
The mechanism of ventilator-induced lung injury (VILI) has attracted considerable attention. Whereas, López-Alonso et al. reported that mechanical ventilation (MV) influenced lung tumour spread in European Respiratory Journal recently, which provides a novel perspective [1]. Such as during respiratory failure or major surgery without removal of tumour, there might exist a potential risk of metastasis by MV for patients with lung tumour. The study verified that mechanical stretch regulated intracellular cholesterol through PCSK9, which in turn preserved cell stiffness and, subsequently, promoted lung tumour spread. In vivo, the mice were injected melanoma cells via jugular vein and were submitted to a 2-h period of MV [peak inspiratory pressure 15 cm H2O, positive end-expiratory pressure (PEEP) 2 cm H2O, 100 breaths/min] or spontaneous breathing, and the results showed that MV increased the tumour invasiveness.
Footnotes
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Conflict of interest: Liu Zhang declares no competing interests.
Conflict of interest: Fang Ying Lu declares no competing interests.
Conflict of interest: Shao Guang Huang declares no competing interests.
Conflict of interest: Qing Yun Li declares no competing interests.
- Received May 24, 2021.
- Accepted September 5, 2022.
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