抽象
背景结核病(TB)的儿童和青少年是正在进行的传输的前哨事件。在荷兰,童年和青少年结核病的流行病学特征尚未充分评估。因此,我们的目的是评估这一人群中的结核病流行病学调查,为消除结核病提供指导。
方法A retrospective time-series analysis using national surveillance data from 1993–2018 was performed in children (aged <15 years) and adolescents (aged 15–19 years) with TB. Poisson regression models offset with log-population size were used to estimate notification rates and rate ratios. Trends in notification rates were estimated using average annual percent changes (AAPC) based on the segmented linear regression analysis.
结果在3899米的儿童和青少年结核病在1993年至2018年通报,2418(62%)是在外国出生的(725 1755名儿童及青少年2144 1693 [78.9%]的[41.3%])。Overall notification rate in children was 2.3/100 000 person-years, declining steadily during the study period (AAPC: −10.9%; 95% CI: −12.6 to −9.1). In adolescents, overall notification rate was 8.4/100 000 person-years, strongly increasing during 1993–2001 and 2012–2018. Compared to Dutch-born, substantially higher notification rates were observed among African-born children and adolescents (116.8/100 000 and 316.6/100 000 person-years, respectively). Additionally, an increasing trend was observed in African-born adolescents (AAPC: 18.5%; 95% CI: 11.9–25.5). Among the foreign-born population, those from countries in the horn of Africa contributed most to the TB caseload.
结论儿童结核病的呈报率很低,在不同的人口群体不断下降。然而,在青少年中所示的非均质性,在增加的趋势外国出生的,特别是那些来自非洲。
脚注
这份手稿最近已接受该出版物欧洲呼吸杂志。据审稿,并通过我们的制作团队排版之前在这里其已接受的形式出版。经过这些生产工艺齐全,作者已经批准了造成证据,文章将移动到的最新一期ERJ线上。请打开或下载PDF,查看这篇文章。
利益冲突:Gafar博士没有透露。
利益冲突:越智先生介绍说,其他活动由BaseClear B.V.(商业,非R&d),提交作品外;.
利益冲突:博士VAN'T Boveneind-Vrubleuskaya有没有透露。
利益冲突:阿克曼博士没有透露。
利益冲突:Erkens博士没有透露。
利益冲突:范登霍夫博士没有透露。
利益冲突:凡博士德WERF有没有透露。
利益冲突:Alffenaar博士没有透露。
利益冲突:Wilffert博士没有透露。
- 收到2020年4月8日。
- 公认2020年5月22日。
- 版权所有©ERS 2020