抽象
还有约衡量儿童支气管高反应性的最合适的方法的争议。在流行病学调查,nonisotonic气溶胶正在越来越多地用于支气管激发试验。我们的目的是研究了两种出版支气管激发试验的可接受性,安全性和相关性。(19例临床诊断轻度至中度哮喘的年龄7-12岁:两个标准化协议 - - 高渗盐水(HS)和超声雾化的蒸馏水(UNDW)的吸入36名儿童进行),以及17个对照组(8-18岁的年龄)。4.5%的生理盐水的HS挑战涉及逐步吸入(0.5,1,2,4和8分钟),而用UNDW挑战是与10分钟吸入冷UNDW的单步协议来执行。哮喘药物之前挑战测试是功不可没的。三十五岁受试者完成7天的时间间隔内都激发试验(一个哮喘病UNDW攻击后没有返回)以随机顺序。对于HS在用力呼气体积>或= 15%减少从基线一秒(FEV1)被认为是阳性反应,而对于一个UNDW>或= 10%的下降。在的19名哮喘患者13,但在无对照的,观察UNDW的积极响应。十五出的18名患者和一个控制对象必须HS的积极响应。 Twelve out of 18 asthmatic children responded to both challenges, three responded only to HS and three had no response to either challenge. There was a negative correlation between log provocative dose causing a 15% reduction in FEV1 (PD15) after HS and the maximum fall in FEV1 after UNDW (rs = -0.63; p < 0.005). The HS challenge had a lower acceptability than challenge with UNDW due to the unpleasant salty taste of HS. However, this did not inhibit the completion of the tests in any subject. The results of this study suggest a good correlation between response to hypertonic saline and ultrasonically-nebulized distilled water in children with mild-to-moderate asthma. A multiple step protocol might be safer when applied in field studies involving children.