% 0期刊文章% Wojnarowski, C %风暴范的Gravesande K % riedl, J为%,Gartner我% C %弗里希,T %比较支气管挑战与超声波喷雾蒸馏水和1996%食盐水在轻度到中度哮喘患儿% D % P J欧洲呼吸杂志》1896 - 1901 X % V 9% N 9%仍有争论最合适的方法来衡量儿童支气管高反应性。在流行病学调查中，非等渗气溶胶正越来越多地用于支气管激发试验。我们的目的是研究两种已发表的支气管激发试验的可接受性、安全性和相关性。两项标准方案——吸入高渗盐水(HS)和超声雾化蒸馏水(UNDW)——在36名儿童中进行:19名临床诊断为轻至中度哮喘的患者(7-12岁)和17名对照受试者(8-18岁)。HS刺激包括逐步吸入4.5%生理盐水(0.5、1、2、4和8分钟)，而UNDW刺激作为单步方案进行，吸入冷UNDW 10分钟。在刺激试验前停止哮喘药物治疗。35名受试者在7天时间间隔内随机顺序完成了两项挑战测试(一名哮喘患者在UNDW挑战后没有返回)。对于HS，一秒内用力呼气量(FEV1) >或= 15%的减少被认为是阳性反应，而对于unw， >或= 10%的减少。在19例哮喘患者中的13例中，未观察到UNDW的阳性反应。18名患者中的15名和1名对照受试者对HS有积极反应。 Twelve out of 18 asthmatic children responded to both challenges, three responded only to HS and three had no response to either challenge. There was a negative correlation between log provocative dose causing a 15% reduction in FEV1 (PD15) after HS and the maximum fall in FEV1 after UNDW (rs = -0.63; p < 0.005). The HS challenge had a lower acceptability than challenge with UNDW due to the unpleasant salty taste of HS. However, this did not inhibit the completion of the tests in any subject. The results of this study suggest a good correlation between response to hypertonic saline and ultrasonically-nebulized distilled water in children with mild-to-moderate asthma. A multiple step protocol might be safer when applied in field studies involving children. %U //www.qdcxjkg.com/content/erj/9/9/1896.full.pdf