TY -的T1 -比较支气管挑战与超声波喷雾蒸馏水和食盐水在轻度到中度哮喘患儿JF -欧洲呼吸杂志》乔和J SP - 1896 LP - 1901欧元六世- 9 - 9盟Wojnarowski C盟——风暴Van Gravesande K盟——riedl J盟——为我非盟——Gartner,C AU - Frischer, T Y1 - 1996/09/01 UR - //www.qdcxjkg.com/content/9/9/1896.abstract N2 -关于测量儿童支气管高反应性的最合适方法仍存在争议。在流行病学调查中，非等渗气雾剂越来越多地用于支气管激发试验。我们的目的是研究两种已发表的支气管激发试验的可接受性、安全性和相关性。两项标准化方案——高渗生理盐水(HS)和超声雾化蒸馏水(UNDW)——在36名儿童中进行:19名临床诊断为轻度至中度哮喘的患者(7-12岁)，17名对照组(8-18岁)。HS刺激包括逐步吸入4.5%生理盐水(0.5、1、2、4和8分钟)，而UNDW刺激则是单步吸入10分钟冷UNDW。哮喘药物在挑战测试前被扣留。35名受试者在7天的时间间隔内按随机顺序完成了两项挑战测试(1名哮喘患者在UNDW挑战后没有返回)。HS a >或= 1秒用力呼气量(FEV1)较基线减少15%被认为是积极的反应，对于UNDW a > or = 10% decrease. In 13 of the 19 asthmatic patients, but in none of the controls, a positive response was observed for UNDW. Fifteen out of 18 patients and one control subject had a positive response to HS. Twelve out of 18 asthmatic children responded to both challenges, three responded only to HS and three had no response to either challenge. There was a negative correlation between log provocative dose causing a 15% reduction in FEV1 (PD15) after HS and the maximum fall in FEV1 after UNDW (rs = -0.63; p < 0.005). The HS challenge had a lower acceptability than challenge with UNDW due to the unpleasant salty taste of HS. However, this did not inhibit the completion of the tests in any subject. The results of this study suggest a good correlation between response to hypertonic saline and ultrasonically-nebulized distilled water in children with mild-to-moderate asthma. A multiple step protocol might be safer when applied in field studies involving children. ER -