摘要
经皮贴片替代尼古丁戒烟比安慰剂更有效,但一年后成功率较低(9-18%)。我们测试了这是否归因于尼古丁替代不足。我们进行了一项随机试验,根据基线血浆可替宁值,研究分层后不同剂量经皮尼古丁替代对预后的影响。297名成年吸烟者参与了研究。基线可替宁<或= 250ng者。ml-1(低可替宁)被随机分配给安慰剂(LC-P)或15 mg 16 h尼古丁贴片(LC-15),基线可替宁> 250 ng。mL-1(高可替宁)随机分为15 mg (HC-15)或25 mg (HC-25) 16 h尼古丁贴片。在治疗期间定时测量血浆尼古丁和可替宁值、过期一氧化碳和戒断症状。LC-15组吸烟者的成功率明显高于安慰剂组(28% vs 9%)。基线可替宁高的吸烟者成功率较低,高剂量尼古丁没有提高成功率(HC-25 9% vs HC-15 11%)。HC-15组的受试者尼古丁替代率最低,脱瘾症状发生率高于HC-25组。 Replacement was similar in groups LC-15 and HC-25, but the success rate was significantly lower in HC-25 group, despite similar levels of withdrawal symptoms. We conclude that a higher success rate was obtained after one year in smokers with low baseline plasma cotinine values. Determination of plasma cotinine values may be, thus, helpful in identifying smokers who could benefit from transdermal nicotine replacement.