TY - JOUR T1 -基线可替宁血浆值在戒烟中的重要性:结果来自尼古丁贴双盲研究JF -欧洲呼吸杂志JO - Eur Respir J SP - 643 LP - 651 DO - 10.1173 /09031936.96.09040643 VL - 9 IS - 4 AU - Paoletti, P AU - Fornai, E AU - Maggiorelli, F AU - Puntoni, R AU - Viegi, G AU - Carrozzi, L AU - Corlando, a AU - Gustavsson, G AU - Sawe, U AU - Giuntini，C Y1 - 1996/04/01 UR - //www.qdcxjkg.com/content/9/4/643.abstract N2 -尼古丁透皮贴片替代戒烟比安慰剂更有效，但一年后成功率较低(9-18%)。我们测试了这是否归因于尼古丁替代品不足。我们进行了一项随机试验，根据基线血浆可替宁值分层后，研究不同剂量经皮尼古丁替代对结局的影响。297名成年吸烟者被纳入研究。基线服用可替宁的;Or = 250 ng。ml-1(低可替宁)被随机分配到安慰剂组(LC-P)或15 mg 16 h尼古丁贴剂组(LC-15)，基线可替宁>组;250 ng。mL-1 (high cotinine) were randomly assigned to 15 mg (HC-15) or 25 mg (HC-25) 16 h nicotine patches. Plasma nicotine and cotinine values, expired carbon monoxide and withdrawal symptoms were measured at scheduled intervals during treatment. Smokers in the LC-15 group had a significantly higher success rate than placebo (28 vs 9%). Smokers with high baseline cotinine had lower success rates, and a high dose of nicotine did not increase success rate (HC-25 9% vs HC-15 11%). Subjects in the HC-15 group had the lowest percentage of nicotine replacement and a higher prevalence of withdrawal symptoms than the HC-25 group. Replacement was similar in groups LC-15 and HC-25, but the success rate was significantly lower in HC-25 group, despite similar levels of withdrawal symptoms. We conclude that a higher success rate was obtained after one year in smokers with low baseline plasma cotinine values. Determination of plasma cotinine values may be, thus, helpful in identifying smokers who could benefit from transdermal nicotine replacement. ER -