抽象的
肺切除对功能能力的影响可以通过不同的方式评估。这项研究的目的是比较肺切除术和肺切除术对肺功能测试(PFT),运动能力和症状感知的影响。68例患者在PFT和运动测试之前接受了功能评估(PREOP),在肺切除后3和6个月进行了功能评估。在50名(36名男性和14个女性;平均年龄61岁)中进行了肺切除术,在18名(13名男性和5名女性;平均年龄59岁)进行了肺切除术。小叶切除术,强迫生命能力(FVC),一秒钟(FEV1),总肺部容量(TLC),碳肺肺肺(TL,CO)的肺转移因子和最大氧气的肺转移因子(V'O2)(V'O2)(V'O2,最大值显着低于Preop值,从切除后的3个月显着增加。肺切除术后三个月,所有参数显着低于前peop值,并且明显低于肉豆制切除术后值,并且在切除后的3到6个月内未恢复。切除后6个月,与PREOP相比,重大缺陷持续存在:对于FVC 7%和36%,FEV1 9%和34%,TLC分别为肺叶切除术和肺切除术的TLC 10%和33%;和V'O2,仅在肺切除术后最大20%。在PREOP的所有患者中,有53%的患者受到腿部肌肉疲劳的限制。肺切除术并没有改变这种情况,但是在切除术后3个月的患者中有61%的患者在切除术后6个月后转向呼吸困难。 Furthermore, pneumonectomy compared to lobectomy led to a significantly smaller breathing reserve (mean +/- SD) (28 +/- 13 vs 37 +/- 16% at 3 months; and 24 +/- 11% vs 33 +/- 12% at 6 months post resection) and lower arterial oxygen tension at peak exercise 10.1 +/- 1.5 vs 11.5 +/- 1.6 kPa (76 +/- 11 vs 86 +/- 12 mmHg) at 3 months; 10.1 +/- 1.3 vs 11.3 +/- 1.6 kPa (76 +/- 10 vs 85 +/- 12 mmHg) at 6 months postresection. We conclude that measurements of conventional pulmonary function tests alone overestimate the decrease in functional capacity after lung resection. Exercise capacity after lobectomy is unchanged, whereas pneumonectomy leads to a 20% decrease, probably due to the reduced area of gas exchange.