抽象的
使用流量中断的呼吸力学预先在健康通风的人的完全呼吸中研究了减轻了关于流动模式的限制的数值技术。发现非牛顿行为的古典线性模型有效。本研究扩展到具有临伤肺病的受试者。急性肺损伤的受试者(Ali; n = 2),急性呼吸窘迫综合征(ARDS; n = 4)和慢性阻塞性肺疾病(COPD; n = 3)进行了,并且没有积极的终端呼气压力(PEEP)。用六氟化硫(SF6)洗涤测量功能性残留能力(FRC)。静压 - 体积(P-V)曲线在零端呼气压力(Zeep)处是线性的,但是窥视下的非线性。它的滞后是不显着的。在Ali / ARDS中,窥视肺部增加肺部量,但只能通过COPD的光泽。在Ali / ARDS中,在Zeep时抗性增加。在COPD中,在Zeep到期期间抵抗变得非常高。 In ALI/ARDS at ZEEP, non-Newtonian behaviour, representing tissue stress relaxation and pendel-luft, complied with the classical linear model. At PEEP, the non-Newtonian compliance became volume-dependent to an extent correlated to the nonlinearity of the static P-V curve. In COPD, non-Newtonian behaviour was adequately explained only with a model with different inspiratory and expiratory behaviour. The classical model of the respiratory system is valid in ALI/ARDS at ZEEP. More advanced models are needed at PEEP and in COPD.