抽象的
一氧化氮(NO)已被鉴定为非肾上腺素能无胆管能支气管神经的神经递质。为了探讨吸入是否没有对慢性阻塞性肺病(COPD)患者进行支气管扩张剂效应,我们使用强制振荡技术测量了呼吸系统的阻力,同时呼吸不。八名患有COPD(7名男子和1名女性;年龄66 +/- 7 YRS(平均+/- SD);强制呼气量在一秒(FEV1)37 +/- 17%的预测)和八个健康的科目(7男性和1名女子; 33 +/- 4 YRS;研究了FEV1 108 +/- 14%pred)。一氧化氮,在空气中以40百份(ppm)的浓度吸入20分钟。呼吸系统的总抗性(RRS)和抗抵抗力(XRS),动脉氧饱和度,心率,潮汐体积和呼吸频率在基线中连续记录,并在停止中停止期间和之后。在健康受试者中另外测量甲昔昔洛宾水平。在基线时,COPD患者比健康受试者显示出更高的RR(10 Hz(RRS,10)4.97 +/- 2.19 Vs 2.29 +/- 0.65 HPA.L-1.S)。在没有吸入期间,观察到RRS或XRS中没有显着变化。RRS的平均变化,10次呼吸的虽然呼吸不计,但在两组中可忽略不计(-0.10 +/- 0.13 HPA.L-1.在COPD患者中, - 0.02 +/- 0.13 HPA.L-1.健康 subjects). Moreover, there were no differences in oxygen saturation, heart rate, tidal volume and breathing frequency during NO inhalation. Methaemoglobinaemia increased at the end of NO inhalation (from 0.48 +/- 0.18 to 0.81 +/- 0.16%), and this increment remained 10 min later (0.86 +/- 0.31%). From these results, we conclude that inhaled nitric oxide, at a concentration of 40 ppm, exerts no effect on respiratory system resistance in patients with chronic obstructive pulmonary disease or in healthy subjects.