摘要
实验室参数可以有助于哮喘的诊断,这往往是一个困难的程序在儿科患者。本研究旨在探讨嗜酸性粒细胞阳离子蛋白(ECP)和嗜酸性粒细胞源性神经毒素(EDN)在小儿哮喘诊断中的价值。测定了22名4-14岁的稳定型过敏性哮喘患儿和17名年龄匹配的健康对照组的嗜酸性粒细胞数量、血清ECP、EDN和尿EDN。在年龄较小的儿童中监测症状,记录呼气峰值流速(PEFR),在年龄较大的儿童中进行肺功能测试(一秒用力呼气量(FEV1)和组胺激发浓度导致FEV1下降20% (PC20))。所有患儿均无呼吸道症状。与对照组相比,哮喘患儿PEFR无显著差异。预测的FEV1 %明显低于对照组。哮喘患儿嗜酸性粒细胞数量、血清ECP、EDN、尿EDN均显著高于对照组。在校正血清ECP和EDN,以及尿EDN中嗜酸性粒细胞数量后,患者和对照组之间的差异消失了。夜间PEFR和FEV1与尿EDN显著相关。 The results suggest that serum and urinary concentration of eosinophil-derived proteins can be determined instead of the number of eosinophils to support the diagnosis of asthma in childhood. The urinary concentration of eosinophil-derived neurotoxin can be especially valuable in young children, because in this age group quantification of lung function cannot be performed and blood sampling can be difficulty.