摘要
导致卡氏肺孢子虫肺炎(PCP)不同风险组不平等死亡率的因素尚不清楚。因此,在这项回顾性研究中,我们比较了未经预防的人类免疫缺陷病毒感染(HIV)患者和其他免疫抑制患者首次发生PCP的情况。共分析了58名艾滋病毒感染者和16名免疫抑制患者。比较包括流行病学、临床、实验室、放射学和微生物学数据,以及治疗和临床过程。使用logistic回归模型进行预后分析。两组的死亡率有显著差异(HIV组17与非HIV组50%)。肾移植患者的生存率高于恶性肿瘤或胶原血管疾病作为潜在的危险疾病。急性呼吸衰竭在非hiv组中更为常见。在单变量分析中发现,与死亡结局显著相关的变量是肺泡-动脉压(P(A-a),O2)、血红蛋白、血小板计数、总蛋白、血清白蛋白和γ -球蛋白,在hiv组和非hiv组的血清白蛋白。在HIV组的多变量分析中,血小板计数和-球蛋白仍然是独立的预后因素。 In conclusion, in the HIV-group, mortality is closely related to the severeness of PCP as well as to the severeness of the acquired immune deficiency syndrome (AIDS) disease. In the non-HIV group, malignancy and collagen vascular disease as underlying conditions at risk account for the high mortality rate. Its severeness was mainly reflected by serum albumin, which represented the only variable found to be significantly associated with death in both groups.