文摘
本研究的目的是通过超声波来描绘两性霉素B气溶胶喷雾和喷气喷雾器和研究他们的沉积和患者的药物动力学肺足分支菌病。空气动力学行为和两性霉素B的肺沉积粒子测量使用药物的直接基于稳定同位素方法标签99矿渣mtc。每个喷雾器板凳检测吸入质量和粒度分布。三个病人患有肺部麴菌瘤为4周的临床研究。他们每天收到5毫克的两性霉素B由Fisoneb或DP100(超声波)或Respirgard II(喷气)喷雾器。沉积放射性标记的两性霉素B与每个喷雾器使用射线照相机测量一次。在两个病人,两性霉素B血清浓度监测气化后在330分钟内完成。吸入大量的三个喷雾器,评为%标记药物在吸气过滤器在重复实验中,包括:Respirgard II 5.8和3.6%;与Fisoneb 28.3%和26.5;DP100 5.9和6.3%。 Mass median aerodynamic diameter (mean +/- SD) results were: 0.28 +/- 0.04 micron with Respirgard II; 4.82 +/- 0.78 microns with Fisoneb; and 2.27 +/- 1.14 microns with DP100. Because of larger particles and significantly greater inhaled mass, Fisoneb delivered more amphotericin B to the central airways, the lung periphery and in the mycetoma lung regions. Amphotericin B serum concentrations correlated with pulmonary deposition and remained below 25 ng.mL-1. No untoward effects were reported by the patients during the 4 week trial.(ABSTRACT TRUNCATED AT 250 WORDS)