摘要
广泛性重症肌无力(MG)患者常伴通气肌受累。目前尚不清楚孤立的眼肌受累患者是否有可识别的通气肌受累。大多数研究都是通过测量肌肉力量来评估肌肉受累程度;然而,我们假设呼吸肌耐力的测量可能是重症肌无力中呼吸肌受累的更敏感的测试。我们研究了17例重症肌无力患者(4例仅累及眼部,13例不同程度的全身性重症肌无力)。在新斯的明注射前和注射后20分钟分别测量肺活量、通气肌力(最大吸气和呼气压力(MIP和MEP))和耐力(2分钟阈值负荷增量试验)。我们将结果与10个正常对照进行了比较。我们发现孤立眼部受累患者与对照组之间无差异。眼肌重症肌无力患者在新斯的明治疗后没有改善。与对照组相比,全身性重力肌无力患者的基线通气肌力(MIP 67 cmH2O(预测值的70%),MEP 86 cmH2O(预测值的50%)和耐力(达到的平均最大负荷= 246 g,最高负荷时的平均压力(P) = 19.4 cmH2O)降低。 After neostigmine, there was a significant increase in MIP in patients with generalized myasthenia gravis and a trend towards an increased MEP. As a group, the patients with generalized myasthenia gravis did not demonstrate a change in their ventilatory muscle endurance after neostigmine; however, there was considerable interpatient variability in response. We conclude that patients with isolated ocular MG have normal ventilatory muscle strength when tested conventionally.(ABSTRACT TRUNCATED AT 250 WORDS)