文摘
治疗慢性严重哮喘是许多患者不满意。这项研究的目的是确定与环孢菌素治疗激素依赖性哮喘的影响。我们进行了双盲,安慰剂对照、随机、平行组试验环孢菌素对肺功能的影响,哮喘严重程度和强的松的圆锥形34激素依赖性哮喘患者(意味着口服强的松的剂量:16 mg.day-1)。这项研究包括:1)基线期(12周);2)实验周期分为两部分:第一部分(12周)环孢菌素或安慰剂治疗;第二部分(22周)环孢菌素或安慰剂治疗和口服强的松减少;和3)随访观察(8周)。哮喘症状评分、肺功能测试(每天最大呼气流量(PEF)和双用力肺活量(FVC),在一秒用力呼气量(FEV1)和最大mid-expiratory流(MEF50),生化和血环孢菌素水平监控整个研究。环孢菌素管理后,轻微的有益影响一些主观观察哮喘严重程度的参数。与此同时,没有注意到有益的对肺功能的影响。 The time trends analysis of mean daily prednisone doses between the treatment groups revealed a statistically significant difference indicating that, during prednisone reduction, cyclosporin seemed to be slightly more efficient than placebo in reducing the requirement for systemic corticosteroid, even though the steroid reduction was accompanied by slight impairment of some pulmonary function. However, there was no significant difference in the final dose reduction between the treatment groups. These data and the known toxicity of the drug suggest a limited place for cyclosporin treatment in steroid-dependent bronchial asthma.