抽象
以前的生理学研究表明,患者肺癌患者的增加与正常或高于正常的肺转移因子相关。这些发现可以解释为肺泡肥大或增生作为这种情况下肺生长的机制。由于通风空间保留正常的弹性特性,我们希望确定肺部肺部生长的机制是增加肺泡数而不是尺寸的结果。肺部扩展性(K)(肺泡尺寸指数),弹性反冲,单尿嘧啶一氧化物转移因子和一氧化碳转移系数(KCO),肺毛细血管血库和肺泡膜扩散能力,以及胸宽在非莫克兵,仇集和正常的男性和女性方面比较,没有肺部大小增加。无论肺部大小如何,所有群体都是正常的肺转移因子。然而,KCO与所有受试者的总肺容量(%预测)与所有受试者的总肺部(预测)与男性的胸部宽度相反。肺毛细血管血量(%预测)与大肺部受试者的受试者的肺部总容量(%预测)与总肺容量(%)的血压成反比。肺部致密性(k),膜扩散能力和弹性反冲在正常范围内。这些发现表明,具有大肺部的受试者的肺泡膜表面积和机械功能。 They also suggest that KCO may not be a reliable guide to the interpretation of the mechanism of lung growth in individuals with disproportionately large lungs, and may be reduced because not all the alveoli are perfused. The normal values for pulmonary distensibility found in all our individuals with large lungs, including acromegalics, suggest that lung growth has been achieved by an increased alveolar number rather than size. However, morphometric studies of the lungs of nonsmoking, acromegalic subjects without lung disease, are required to substantiate this finding.