文摘
近年来,白介素2(2)作为免疫调节治疗各种恶性肿瘤。然而,这种治疗一直受到严重的副作用,包括肺毒性反应。- 2治疗炎性细胞数量的影响在正常和辐照鼠肺在本研究调查。是持续皮下输注在管理- 2 6周的研究。辐照是一剂(25 Gy) - 2治疗开始后的第二天。评估和支气管肺泡灌洗液(BALF)和肺组织形态学分析辐照后4 - 6周。在未照射大鼠,治疗- 2诱导显著增加血管周围炎症细胞的总数,间质在肺泡和支气管旁组织以及空间。这些增加不是BALF中反映出来;相反,明显降低炎症细胞的总数是BALF中找到。辐照引起更明显的炎症反应是显著增加炎症细胞肺隔间,也是BALF中反映出来。 Concomitant treatment with IL-2 and irradiation induced an enhanced accumulation of inflammatory cells in the perivascular and peribronchial tissues compared with irradiation alone. Thus, both irradiation and IL-2 treatment induce inflammatory reactions in the lung, but there were signs of synergistic effects seen in this study. Furthermore, the results also emphasize the difficulties in making sophisticated conclusions from BALF analyses alone.