摘要
已经表明,在呼吸暂停中观察到的肺气体干扰慢性重复环境缺氧导致大鼠的全身高血压。然而,缺氧(HO),Hypercapnnia(HC),气体应激和警惕对心血管变化的相对作用尚未得到证实。本研究的目的是研究在单独和HO + HC大鼠大鼠的重复吸入各种气体混合物期间观察到的急性血动力学变化,并分析了警惕和气体施用应力的影响。我们研究了6只由主动脉导管慢性仪表的6只未享受的Wistar大鼠。氮气,氮+二氧化碳混合物和压缩空气被随机施用在有机玻璃室中以10秒,然后通过压缩空气冲洗20秒。每分钟重复两个循环10至12分钟。通过O2和CO 2分析仪监测吸入的气体级分(FI,O 2,FI,CO2)。通过P23XL换能器测量血压(BP)。通过1306 IL表分析血液。在对照实验中,单独具有压缩空气,心率(HR)和BP没有显着的急性变化。 During HO there were no changes in HR or BP at FI,O2 values from 0.05-0.14, whilst at FI,O2 values from 0-0.05 systolic blood pressure (SBP) rose significantly (+25.3 +/- 25.7 (SD) mmHg) and HR decreased (-93.8 +/- 124.1 bpm). During HOHC, SBP rose (+35.1 +/- 26.4 mmHg) and HR decreased (-139.3 +/- 75.7 bpm), significantly more than in HO alone. SBP was linearly correlated with Pa,O2 during HO (r = 0.53) and also during HOHC (r = 0.44) and was not directly related to Pa,CO2 which has, nevertheless, an additive effect to HO. SBP rose with each challenge significantly more when the rats were awake than when asleep (behavioural sleep). We conclude that in this acute repetitive inhalation model, the rise in SBP is not related to gas stress or to Pa,CO2 but to a decrease in Pa,O2 and is enhanced by wakefulness.