TY - T1的心血管变化在大鼠急性情景重复缺氧和呼吸hypercapnic JF -欧洲呼吸杂志》乔和J SP - 1675 LP - 1680欧元六世- 8 - 10盟Bakehe M盟——Miramand杰盟——Chambille B非盟-高提耶,C AU - Escourrou,已经证明，慢性重复的环境缺氧，模拟呼吸暂停时观察到的肺气体干扰，可导致大鼠全身性高血压。然而，缺氧(hypoxia, HO)、高碳酸血症(high capnia, HC)、气体应激和警惕性对心血管变化的相对作用尚未得到证实。本研究旨在观察HO单用和HO+HC重复吸入不同气体混合物对大鼠急性血流动力学的影响，并分析警惕和给药应激的影响。我们研究了6只未麻醉的Wistar大鼠，慢性置入主动脉导管。氮气、氮气+CO2混合物和压缩空气在有机玻璃室中随机注入10 s，然后用压缩空气冲洗20 s。每分钟重复2个循环，持续10 ~ 12分钟。通过O2和CO2分析仪监测吸入气体组分(FI、O2、FI、CO2)。血压(BP)由P23XL传感器测量。血气由1306 IL仪分析。在单独使用压缩空气的对照实验中，心率(HR)和血压没有显著的急性变化。 During HO there were no changes in HR or BP at FI,O2 values from 0.05-0.14, whilst at FI,O2 values from 0-0.05 systolic blood pressure (SBP) rose significantly (+25.3 +/- 25.7 (SD) mmHg) and HR decreased (-93.8 +/- 124.1 bpm). During HOHC, SBP rose (+35.1 +/- 26.4 mmHg) and HR decreased (-139.3 +/- 75.7 bpm), significantly more than in HO alone. SBP was linearly correlated with Pa,O2 during HO (r = 0.53) and also during HOHC (r = 0.44) and was not directly related to Pa,CO2 which has, nevertheless, an additive effect to HO. SBP rose with each challenge significantly more when the rats were awake than when asleep (behavioural sleep). We conclude that in this acute repetitive inhalation model, the rise in SBP is not related to gas stress or to Pa,CO2 but to a decrease in Pa,O2 and is enhanced by wakefulness. ER -