提炼
Observational studies have shown that low vitamin D levels are associated with decreased lung function, worse asthma control, and lower quality of life in children with asthma [1–3]. Moreover, a small randomised imbalanced placebo-controlled trial reported that vitamin D supplementation improved asthma control, but not lung function measures, after 2 months of treatment. In that trial, children were not selected based on low vitamin D levels, asthma management was not standardised across treatment arms, and a low dose of vitamin D (800 IU per day) was used in the treatment arm [4].
抽象的
与安慰剂相比,补充维生素D的补充对预测的肺功能度量(FEV1,FVC或FEV1/FVC),哮喘控制或哮喘儿童中与维生素D水平低的儿童的生活质量无显着影响https://bit.ly/3ibbt4u
Acknowledgements
我们要感谢所有研究参与者及其家人,每个研究站点的研究协调员和研究团队以及数据协调中心;数据和安全监控委员会;联邦机构(National Heart,肺部和血液研究所)的联邦机构的临床试验专家(Julie Bamdad)和计划官(Patricia Noel),用于监测研究的进度。
脚注
试用注册:Clinicaltrials.gov标识符NCT02687815。Requests for de-identified data from this clinical trial should be made to the corresponding author. Following completion of a signed data access agreement for a specified purpose (例如一项荟萃分析),其拟议使用数据的研究人员将从2020年12月15日开始,将获得研究参与者的识别数据和该临床试验的数据词典。
Author contributions: Y-Y. Han, E. Forno and J.C. Celedón conceived and designed the study; Y-Y. Han and J. Luther conducted the primary analysis; Y-Y. Han, E. Forno, F.J. Rosser and J.C. Celedón interpreted the data; E. Forno, L.B. Bacharier, W. Phipatanakul, T.W. Guilbert, M.D. Cabana, K. Ross, J. Blatter, F.J. Rosser, S. Durrani, S.R. Wisniewski and J.C. Celedón participated in data collection; Y-Y. Han prepared the first draft of manuscript. All authors reviewed the draft for intellectual contents, and approved submission of the final version of the manuscript.
利益冲突:Y-Y。韩没有什么可披露的。
Conflict of interest: E. Forno has nothing to disclose.
利益冲突:第2 Bacharier nothing to disclose.
Conflict of interest: W. Phipatanakul reports personal fees for consultancy from GSK, Genentech, Novartis, Regeneron, Sanofi and Teva, grants from Genentech, Novartis, Regeneron, Sanofi, Circassia, Monaghen, Thermo Fisher, Alk Abello, Lincoln Diagnostics, GSK, Kaleo and Merck, institutional grants from Genentech, Regeneron, Novartis and the US NIH, outside the submitted work.
利益冲突:T.W。Guilbert报告了美国儿科委员会(儿科肺子板),GSK,TEVA和SANOFI/REGENERON的个人费用。
Conflict of interest: M.D. Cabana is a member of the United States Preventive Services Task Force (USPSTF), outside the submitted work.
利益冲突:K。Ross没有什么可披露的。
利益冲突:J。Blatter没有什么可披露的。
Conflict of interest: F.J. Rosser has nothing to disclose.
Conflict of interest: S. Durrani has nothing to disclose.
利益冲突:J。Luther无话可说。
利益冲突:S.R。Wisniewski没有什么可披露的。
Conflict of interest: J.C. Celedón reports non-financial support (study medication) from Pharmavite and GSK, during the conduct of the study; non-financial support (study medication) from Merck, outside the submitted work.
支持声明:本研究是由格兰特HL119952 from the US National Institutes of Health (NIH). The project was also supported by the Pediatric Clinical and Translational Research Center (PCTRC) at the University of Pittsburgh Medical Center Children's Hospital of Pittsburgh through NIH grant UL1TR001857. F.J. Rosser's contribution was supported by grant KL2 TR001856 from the NIH. Pharmavite LLC provided the vitamin D and placebo capsules for the study, and GlaxoSmithKline provided the Flovent given to study participants. Funding information for this article has been deposited with theCrossref Funder Registry。
- 已收到April 4, 2021.
- Accepted2021年7月6日。
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