提炼
自从超过20亿年前的大氧化事件以来,适当的氧气对地球的生命至关重要。有氧代谢需要氧气在线粒体中产生能量。缺氧是指组织中低于正常氧部分压的情况,这可能是由于低氧血症或氧气递送到组织,细胞摄取或细胞内利用的损害。肺部和全身循环中存在补偿机制,并且不同细胞类型在有限的缺氧时期具有不同程度的耐受性,但是这些适应性的失败或精疲力尽会导致细胞死亡[1]。通常使用补充氧气来纠正低氧血症,通常以氧饱和靶标为指导。不适当,缺乏或无视的上限和下限可能会导致高氧或缺氧的延长。
抽象的
Clinical practice regarding oxygen therapy is changing, with increasing evidence that hyperoxia should be avoided. The lower oxygen target ranges need ongoing evaluation: a careful approach, including assessment of an individual's risks, is needed.https://bit.ly/3HNTGVV
脚注
作者贡献:B.R。米勒对手稿有了最初的想法。C. Yu和B.R.米勒写了手稿。
Conflict of interest: C. Yu has nothing to disclose.
Conflict of interest: B.R. Miller has received Intermittent payments for advice on specific applications for Oxygen Therapy in their capacity as a clinical advisor on Domiciliary Oxygen Therapy to the Department of Health and Human Services, Victoria, Australia.
- 已收到2021年4月9日。
- 公认2021年5月17日。
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