Extract
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, age-related interstitial lung disease. Incidence of IPF in the USA ranges between 14 and 63 per 100 000 people [1]. The average survival rate from the time of diagnosis is 3–5 years. IPF is associated with several genetic and environmental factors. Genes associated with a risk for developing IPF generally fall into two categories: epithelial cell genes (e.g. MUC5B, DSP, SFTPA2, ABCA3) or genes involved in telomere maintenance (e.g. TERT, TERC, RTEL1) [2, 3].
Abstract
Mitochondrial antiviral signalling protein (MAVS) mediates pulmonary fibrosis by regulating cGAS-STING and senescence programming https://bit.ly/35Tijjj
Footnotes
Conflict of interest: R.P. Naikawadi has nothing to disclose.
Conflict of interest: P.J. Wolters reports grants and personal fees from Boehringer Ingelheim and Roche/Genentech, personal fees from Gossamer Bio, Blade Therapeutics and Pliant, outside the submitted work.
- Received December 11, 2020.
- Accepted January 11, 2021.
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