TY - T1的飞行器(S)埃里克线粒体:unconventional role for mitochondrial antiviral signalling protein in pulmonary fibrosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.04500-2020 VL - 57 IS - 4 SP - 2004500 AU - Naikawadi, Ram P. AU - Wolters, Paul J. Y1 - 2021/04/01 UR - //www.qdcxjkg.com/content/57/4/2004500.abstract N2 - Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, age-related interstitial lung disease. Incidence of IPF in the USA ranges between 14 and 63 per 100 000 people [1]. The average survival rate from the time of diagnosis is 3–5 years. IPF is associated with several genetic and environmental factors. Genes associated with a risk for developing IPF generally fall into two categories: epithelial cell genes (e.g. MUC5B, DSP, SFTPA2, ABCA3) or genes involved in telomere maintenance (e.g. TERT, TERC, RTEL1) [2, 3].Mitochondrial antiviral signalling protein (MAVS) mediates pulmonary fibrosis by regulating cGAS-STING and senescence programming https://bit.ly/35Tijjj ER -