Abstract
Background:Diaskintest (DST) is Mycobacterium tuberculosis-specific recombinant protein CFP10-ESAT6 for skin test (0.2 mcg/0.1 ml) using the way of tuberculin skin testing (TST).
Aim:To evaluate the effectiveness of two approaches to the screening for TB infection in children in Moscow given their 90%-BCG-vaccination coverage.
Methods:定义了两组:675,926名0-7岁的儿童(I组)和834121名8-17岁儿童(II组)。与上一年相比,在第I组,然后在TST反应增加的情况下,用2 tu PPD进行了TST;DST是II组唯一进行的测试。为了排除活性结核病(TB),所有患有阳性DST反应的儿童进行了计算机断层扫描。那些没有结核病的人被认为是潜在的结核感染(LTBI)病例,并接受了预防疗法(PT)。
Results:In 2018 in group I positive TST reactions (>5mm) were observed in 70.4% (n=475852). DST was performed in 21803 (4.6%) of them, positive reactions were observed in 2% (n = 444). Among them, TB detection rate was 3.4% (n = 15), post-tuberculous changes - 6.5% (n = 29). To compare with TST alone, the predicted detection rates would be 50 times lower (0.07 and 0.13%, respectively), p<00001. In group II, positive DST reactions were observed in 0.35% (n = 2577). TB detection rate was 0.8%, post-tuberculous changes - 5.2%. Our studies for the last 5 years demonstrate, that preventive therapy only for DST-positives significantly decreases TB infection reservoir and promotes reduction of the incidence rate in children general population.
Conclusion:DST screening combines high efficiency, cost-effectiveness and convenience.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2809.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available atwww.ers-education.org(ERS member access only).
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