@文章{Slogotskaya2809，作者= {Slogotskaya, Ludmila和Bogorodskaya, Elena和Sinitsyn, Mihail和Nikolenko, Nikolay和Kudlay, Dmitriy和Shamuratova, Luisa和Sevostyanova, Tatiana}，标题={使用结核杆菌素和重组过敏原皮肤试验筛查儿童结核病感染(CFP-10-ESAT-6)}，卷={56}，编号= {suppl 64}，位置-id ={2809}，年份= {2020}，doi ={10.1183/13993003.大会-2020.2809}，出版商={欧洲呼吸学会}，188bet官网地址背景:Diaskintest (DST)是结核菌特异性重组蛋白CFP10-ESAT6皮试(0.2 mcg/0.1 ml)，采用结核菌素皮试(TST)的方法。目的:评估莫斯科儿童结核感染筛查的两种方法的有效性，考虑到其90%的bcg疫苗接种覆盖率。方法:将0-7岁儿童675,926例(I组)和8-17岁儿童834121例(II组)分为两组，I组采用TST加2 TU PPD, TST反应较前一年增加的采用DST -;DST是第二组唯一的测试。为了排除活动性结核病(TB)，所有dst反应阳性的儿童都进行了计算机断层扫描。无结核者视为潜伏性结核感染(LTBI)病例，给予预防治疗(PT)。结果:2018年I组TST阳性反应(\>5mm)占70.4% (n=475852)。其中21803例(4.6\%)进行了DST, 2\% (n = 444)观察到阳性反应。其中结核检出率为3.4 % (n = 15)，结核后病变- 6.5 % (n = 29)。与单独使用TST相比，预测检出率将降低50倍(分别为0.07和0.13%)，p\<00001。ⅱ组的DST阳性反应为0.35% (n = 2577)。 TB detection rate was 0.8\%, post-tuberculous changes - 5.2\%. Our studies for the last 5 years demonstrate, that preventive therapy only for DST-positives significantly decreases TB infection reservoir and promotes reduction of the incidence rate in children general population.Conclusion: DST screening combines high efficiency, cost-effectiveness and convenience.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2809.This abstract was presented at the 2020 ERS International Congress, in session {\textquotedblleft}Respiratory viruses in the "pre COVID-19" era{\textquotedblright}.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/56/suppl_64/2809}, eprint = {//www.qdcxjkg.com/content}, journal = {European Respiratory Journal} }