Extract
It has consistently been shown that patients with sickle cell disease (SCD) exhibit a compensatory increase in pulmonary capillary blood volume (PCBV), at least in a specific subgroup of patients [1]. This increase in PCBV could be related to the anaemia-induced increase in cardiac output [2]. Chaudryet al.[3] showed that SCD patients failed to recruit and dilate their pulmonary capillary bed to the same extent as control subjects for a given rise in effective pulmonary blood flow. One may therefore hypothesise that PCBV is already maximally recruited at rest; however, this has yet to be confirmed. Furthermore, it is not clear whether this potential defective pulmonary vascular recruitment is related to SCD history.
抽象
镰状细胞疾病的儿童具有肺部毛细血管血容量,其已经在休息时扩张,并且可能引起限制性缺陷https://bit.ly/2MRaqkc
Acknowledgements
P. Bokov and C. Delclaux thank Nicole Beydon for initiating the subject of the present study.
脚注
利益冲突:P. Boizeau没有什么可披露的。
Conflict of interest: J. Pautrat has nothing to disclose.
利益冲突:F. Missud没有任何披露。
Conflict of interest: A. Ba has nothing to disclose.
利益冲突:Z.Haouari无需披露。
利益冲突:A. Denjean无需披露。
Conflict of interest: C. Delclaux has nothing to disclose.
Conflict of interest: M. Benkerrou has nothing to disclose.
Conflict of interest: P. Bokov has nothing to disclose.
支持声明:该研究得到了援助刊登 - HôpitauxdeAlis。本文的资金信息已存入Crossref Funder Registry.
- 收到February 21, 2020.
- Accepted2020年6月5日。
- 复制right ©ERS 2020