Extract
Pulmonary arterial hypertension (PAH) is characterised by progressive obliteration of the pulmonary vasculature, culminating in right-sided heart failure (HF). In recent years, studies have observed an association between systemic metabolic dysfunction, PAH and right ventricular failure [1]. Patients with PAH have an increased prevalence of obesity [2] and type 2 diabetes [3, 4]. Interestingly, abnormal glucose metabolism is evident even in non-diabetic individuals with PAH [5–7], and serves as an independent predictor of prognosis [8].
Abstract
葡萄糖和脂肪代谢在pulmonar改变y arterial hypertension, but it is not yet clear if these changes are causes or effects of the diseasehttp://bit.ly/3cWyf66
Footnotes
Conflict of interest: D. Duan has nothing to disclose.
Conflict of interest: C. Gu has nothing to disclose.
Conflict of interest: J.C. Jun has nothing to disclose.
Support statement: This work was supported by the National Institutes of Health (T32DK062707 to D. Duan), American Heart Association (Postdoctoral Fellowship Award 20POST35210763 to C. Gu), National Institutes of Health (R01HL135483 to J.C. Jun). Funding information for this article has been deposited with theCrossref Funder Registry.
- ReceivedFebruary 26, 2020.
- AcceptedFebruary 29, 2020.
- Copyright ©ERS 2020