Abstract
横断面研究表明,阻塞性睡眠呼吸暂停(OSA)和代谢综合征(MetS)通常是相关的,但是是否存在时间关系是未知的。我们旨在调查OSA对普通人群发展大都会的风险的影响。
A prospective study was conducted combining two population-based samples: Episono (Brazil) and HypnoLaus (Switzerland). MetS was assessed according to unified criteria. Polysomnography (PSG) was performed at baseline and follow-up in Episono, and at baseline in HypnoLaus. OSA was defined according to the apnoea–hypopnoea index as mild (≥5– <15 events h-1)和中度至重度(≥15事件·H-1)。我们包括1853名参与者(平均值±SDage 52±13 years, 56% female) without MetS at baseline.
After mean±SD6±1 years, 318 (17.2%) participants developed MetS. Moderate-to-severe OSA was independently associated with incident MetS (OR 2.58, 95% CI 1.61–4.11) and increased the number of MetS components from baseline to follow-up through mediation of the percentage of time with arterial oxygen saturation <90%. Subset analysis in Episono confirmed that the increase in this parameter between baseline and follow-up PSGs represented a risk factor for incident MetS (OR 1.42, 95% CI 1.04–1.95, for each 10% increase).
OSA与普通人群中夜间低氧血症的介导,与增加大会的风险增加了。
Abstract
OSA is an independent risk factor for incident metabolic syndrome (MetS) through mediation of nocturnal hypoxaemia in the general population. Conversely, MetS does not appear to be independently associated with incident OSA.http://ow.ly/anky30m2vn4
Footnotes
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作者贡献:C。Hirotsu,J。Haba-Rubio,S.M。Togeiro,L.F。Drager,L。Bittencourt,R。Heinzer和S. Tufik设计了这项研究。C. Hirotsu,J。Haba-Rubio,L。Bittencourt,R。Heinzer和S. Tufik是研究人员,招募患者并收集了研究数据。所有作者都为数据解释做出了同样的贡献,参与了手稿的批判性审查和修订,并获得了提交的最终批准。
利益冲突:C。Hirotsu无需披露。
利益冲突:J。Haba-Rubio无话可说。
利益冲突:S.M.Togeiro没有什么可披露的。
利益冲突:P。Marques-Vidal没有什么可披露的。
Conflict of interest: L.F. Drager has nothing to disclose.
Conflict of interest: P. Vollenweider reports grants from GlaxoSmithKline, during the conduct of the study.
利益冲突:G。Waeber无话可说。
利益冲突:L。Bittencourt没有什么可披露的。
利益冲突:S。Tufik无话可说。
利益冲突:r·海因策报告收到fees as a member of the medical advisory boards of Nightbalance and Rhythm as well as grants from Fondation Leenaards and the Ligue Pulmonaire Vaudoise.
支持声明:COLAUS的研究得到了葛兰素史克,洛桑(FBM)生物学和医学学院(FBM)和瑞士国家科学基金会(SNF赠款33CSCO-1122661,33CS30-139468和33CS30-148401)的研究。Episono研究得到了AssociaçãoFundodeIctentivoàPesquisa(AFIP)和圣保罗研究基金会(FAPESP GRANT 2014/15259-2)的研究赠款的支持。本文的资金信息已存入CrossRef资助人注册表。
- ReceivedJune 19, 2018.
- 公认2018年9月24日。
- Copyright ©ERS 2018