From the authors:
We would like to thank N. Okhura and co-workers for their interest in our manuscript and are pleased that they were able to reproduce our data in their laboratory. The length of time that the guinea pigs are monitored following a tussive challenge may well be important for obtaining a true and accurate picture of whether the cough reflex has been affected by interventional agents. We would question, however, whether the observation that β2- agagists抑制豚鼠模型中的咳嗽1实际上争论诊所中的传统智慧。这可能只是在最佳实验范式中客观地评估这个问题。有几篇论文可以观察β的镇咳效应2一方面2-7.还有一些没有8.那9.and, as such, we have proposed in our paper that we may have an answer as to why this confusion may exist. First, in most cases, β2受体激动剂尚未评估在双盲,placebo-controlled, randomised, crossover clinical trials where cough is the primary end point. Furthermore, there has only been symptom scoring and no objective measurement of cough. This is important given patients (especially those with chronic cough) find it very difficult to make an accurate assessment of their own cough. As such, there are issues with the subjective nature of the reporting of cough as a symptom; objective cough monitoring devices have only recently been developed and trials with β2尚未进行的角度。然而,报告咳嗽的不同临床研究之间的差异也可能是由于β的事实2- 一个角度激活一个独立于其平滑肌松弛活性的特定抗肌肉机制(如本文所示)。目前,β的剂量方案/方案2诊所的角度是常规基于他们的休闲物质而不是追溯到他们的休战活动(可能需要更高剂量的休息活动),我们建议这可能是β的主要抗肌肉性质的原因2一方面has not hitherto been uncovered.
Footnotes
S.tatement of Interest
None declared.
- ©ers 2010.