摘要
我们之前已经证明AutoSet能够令人满意地改善阻塞性睡眠呼吸暂停综合征(OSA)患者的睡眠紊乱呼吸和睡眠结构。本研究的目的是确定在AutoSet推荐压力下长期接受常规固定压持续气道正压(CPAP)治疗的受试者,其长期依从性是否令人满意;一旦最初的反弹结束,这种改善就会持续;滴定压力随时间变化稳定;滴定压力可与使用相似终点的手动滴定压力相媲美。20名男性阻塞性睡眠呼吸暂停(OSA)患者在诊断之夜进行了完整的多导睡眠描记术、手动和AutoSet滴定法以及AutoSet推荐固定压力法的研究,在推荐固定压力下平均治疗3个月和8个月后再次进行了研究。再研究包括家庭呼吸监测(Nellcor EdenTrace),重复手动和多导睡眠描记仪自动滴定。依从性评估时计读数。平均(+/- sem)使用5.7 +/- 0.1 h夜间-1在3和8个月。唤醒指数保持正常。 Diagnostic respiratory disturbance index (RDI) was 60.3 +/- 5.7 events.h-1. On AutoSet at fixed CPAP, RDI was initially 2.6 +/- 0.7 events.h-1, then rose slightly (p < 0.001) to 4.3 +/- 0.6 events.h-1 at 3 months, and was 3.6 +/- 0.5 events.h-1 at 8 months. AutoSet titration pressure was: 9.9 +/- 0.4 cmH2O initially, 10.6 +/- 0.4 cmH2O at 3 months, and 9.7 +/- 0.5 cmH2O at 8 months (NS). Manual titration pressure at 8 months was 10.4 +/- 0.4 cmH2O. The standard deviation of the discrepancy with AutoSet was 0.84 cmH2O. In conclusion, the AutoSet recommended pressure varies little with time, and closely predicts the final manual titration pressure; the improvement in respiratory disturbance index was largely maintained, and compliance was good, although probably enhanced by close supervision.