抽象的
在青春期,一些儿科哮喘患者将无症状,不需要进一步治疗。有关这些患者的特应地位,肺功能和支气管反应性的信息很少。在治疗终止后1年评估了7.7-19.2 YRS的无症状哮喘患者(N = 118)。支气管哮喘以前在经常性喘息发作的基础上被诊断出来。通过皮肤刺测试评估特应地位。基线肺功能通过肺活量测定,流量曲线和体积描记法测定。通过冷水干燥空气挑战,非武装的支气管反应性被评估。八十一名患者至少有一个阳性皮肤试验结果,其余37个被定义为非含量。在Atopic受试者中,支气管高反应性的患病率显着高于非植物患者(41例,81分,而7分别为37; P = 0.001)。Atopic受试者显示出明显较低的最大呼气流量,剩余的呼气量为25%,剩余的重要容量(P <0.05)和比非含量受试者更高的残留体积(P <0.05)。 Nonatopic subjects were significantly younger than atopic patients (p<0.01). These symptom- and medication-free paediatric and adolescent asthma patients could, thus, be divided into two groups: 1) atopic subjects with a tendency towards bronchial hyperresponsiveness; and 2) nonatopic subjects with better lung function and normal bronchial responsiveness In view of the increased understanding of the epidemiology of early childhood wheezing, these findings support the concept of different pathogenic mechanisms underlying wheezing episodes in early childhood.