抽象
无症状支气管高反应性(BHR)的临床意义是众所周知的。本研究的目的是在横截面分析中探讨,与非高压审查和有症状性BHR的那些,与无症状BHR的青少年受试者的特征。从一般从业者登记者出生日期选择受试者。在历史队列分析中,还测试了无症状和症状性BHR与早期儿童较早呼吸道感染有关的假设。在儿童早期和青春期的早期和BHR中研究了呼吸司和BHR,在551岁的人群中,551岁以上的10-23 YRS。自从一般练习中出生以来,发病率已经前瞻性记录。在这次调查期间收集了慢性呼吸系统症状,吸烟行为,气道阻塞,BHR和过敏的数据。BHR存在于42%的受试者中,其中70%是无症状的。症状性BHR的发生与早期儿童早期,过敏,气道阻塞和最近的哮喘,急性支气管炎和花粉发热的急性支气管炎有关;而无症状的BHR不是。 Characteristics of subjects with asymptomatic BHR did not differ significantly from those without BHR, with respect to these factors. We conclude that asymptomatic bronchial hyperresponsiveness in adolescence and young adulthood is not related to lower respiratory infections in early childhood. Furthermore, subjects with asymptomatic bronchial hyperresponsiveness have similar characteristics to those without bronchial hyperresponsiveness, but differ strongly from subjects with symptomatic hyperresponsiveness. Asymptomatic bronchial hyperresponsiveness may not be the link between early childhood lower respiratory morbidity and asthma in later life, nor a risk factor for later asthma.