摘要
本研究的目的是确定肺泡扩张和表面活性物质功能障碍对肺泡鼻尖屏障功能的影响是否存在差异和叠加性。使用喷雾化锝-99m标记的人血清白蛋白(99mTc-HSA)的肺清除率来表征用洗净剂丁二酸二辛钠扰乱表面活性剂系统后的屏障功能,无论是单独或联合大潮气容量通气(LTVV)。测量四组(每组6只)兔3小时(实验通气)的清除率:1)对照组;2)洗涤剂;3) LTVV;4)洗涤剂+ LTVV。在常规通风条件下研究了3小时的间隙恢复。在LTVV(305分钟)期间,与对照组的1055分钟相比,清除的半衰期(t1 /2)降低了。洗涤剂诱导双指数清除,慢半衰期(t1 / 2s)和快半衰期(t1 / 2f)分别为670和15.4分钟。快速分数(fF)是0.20。 Clearance in the Detergent + LTVV group was also biexponential. The t 1/2F and fF were similar to the Detergent group. The t 1/2S was similar to the LTVV group. The fF in this group increased to 0.36 during Recovery (p < 0.01 versus Detergent group and p < 0.05 versus Experimental ventilation). The diverse kinetics of clearance during large tidal volume ventilation and surfactant dysfunction suggest the presence of different mechanisms affecting the barrier. The mechanisms have additive characteristics, which superimpose to produce lung injury.