TY -的T1 -膨胀添加剂的性质和表面活性剂微扰alveolocapillary渗透率JF -欧洲呼吸杂志》乔和J SP - 192 LP - 199欧元六世- 10 - 1 AU -约翰,J盟——Taskar V AU -伊万,E盟——Wollmer P AU -琼森,本研究的目的是确定肺泡扩张和表面活性剂功能障碍对肺泡毛细血管屏障功能的影响是否不同和可加性的。使用锝-99m标记的人血清白蛋白(99mTc-HSA)的肺清净来表征清洁剂二辛基磺基琥珀酸钠单独或联合大潮气量通气(LTVV)扰乱表面活性剂体系后的屏障功能。测量4组(n = 6)兔子3 h(实验通气)的间隙:1)对照组;2)洗涤剂;3) LTVV;4)洗涤剂+ LTVV。在常规通气条件下研究间隙恢复(Recovery) 3 h。与对照组的1055分钟相比，LTVV(305分钟)清除半衰期(t1 /2)降低。洗涤剂的半衰期为670 min，半衰期为15.4 min。 The fast fraction (fF) was 0.20. Clearance in the Detergent + LTVV group was also biexponential. The t 1/2F and fF were similar to the Detergent group. The t 1/2S was similar to the LTVV group. The fF in this group increased to 0.36 during Recovery (p < 0.01 versus Detergent group and p < 0.05 versus Experimental ventilation). The diverse kinetics of clearance during large tidal volume ventilation and surfactant dysfunction suggest the presence of different mechanisms affecting the barrier. The mechanisms have additive characteristics, which superimpose to produce lung injury. ER -