抽象的
本研究旨在确定多发性硬化症(MS)中肺功能,呼吸肌功能和神经功能之间的关系。左右研究了六十名患者(27名男性和33名女性)(平均+/- SD 48 +/- 12 YRS)。Kurtzke扩大残疾状态规模(EDSS;范围0-10)得分为6.5 +/- 1.5;和不同的功能系统得分(FSS; 0-5和0-6)是:金字塔3.4 +/- 1.1;脑干1.9 +/- 1.2;心理1.3 +/- 0.9;小脑2.2 +/- 1.0;括约肌1.8 +/- 1.5;Visual 1.4 +/- 1.4;和感觉2.0 +/- 1.5。 Results of lung function tests were: vital capacity (VC) 80 +/- 23% of predicted; single-breath transfer factor of the lung for carbon monoxide (TL, CO, sb) 83 +/- 17% pred; maximal static expiratory mouth pressure (MEP) 30 +/- 16% pred; and maximal static inspiratory mouth pressure (MIP) 47 +/- 23% pred, indicating a marked respiratory muscle dysfunction, with a minor restrictive defect. In 70% of the patients, a transcutaneous oxygen saturation (Stc, O2) of less than 92% at night was found. Comparison of lung function and disability scores showed that the abnormalities in both tended to be correlated to each other, and that this was significant for EDSS versus lung volumes, for most FSS with VC, and also for some FSS with MEP and/or MIP. Duration of disease was significantly correlated with the EDSS, but not with the different FSS scores (with the exception of mental status) and not with lung function. Multiple sclerosis leads to lung function abnormalities attributable to respiratory pump dysfunction.