摘要
我们研究了以已知浓度(接近阈限值-短期暴露极限(TLV-STEL) 10 mg.m-3)通过特殊设备输送的锯末颗粒对12名对该产品没有临床致敏的哮喘受试者的FEV1和PC20的影响。受试者被研究超过两天(第1天:暴露于锯末;第2天:假暴露)随机顺序,最长间隔1周。每一天,在肺量测定和PC20评估后,受试者接受木屑暴露或假暴露。锯末被吸入30分钟,平均浓度从8.0到19.3 mg不等。m-3(平均= 11.5 mg.m-3)。25 ~ 39.7%(平均= 34.6%)吸入颗粒物的直径小于10 mu(可沉积于气管和下呼吸道的直径)。在每个暴露期结束时,评估FEV1。回收后得到第二个PC20。在暴露结束后6小时内,每小时连续测量一次FEV1。当时,对PC20进行了重新评估。 Only one subject showed an acute bronchoconstriction immediately after exposure to sawdust (maximum fall of 14% in FEV1) with complete recovery 10 min later. Overall, inhalation of sawdust did not modify PC20 by comparing the mean result of the first test with the second and the third assessments. Also, the mean changes in PC20 at each interval after exposure to sawdust were not significantly different from the variations in PC20 on the sham day.(ABSTRACT TRUNCATED AT 250 WORDS)