Extract
Historically, it was widely believed that the lower respiratory tract was sterile in health, a “dogma” based on the fact that studies previously employing extensive microbiological culturing of airway samples could not identify the presence of any commensal bacteria. However, the vast majority of respiratory bacteria are recognised to be unculturable by traditional methods and so it has required the application of highly sensitive molecular microbiological techniques, such as 16S rRNA sequencing, to irrefutably demonstrate the existence of complex communities of symbiotic bacteria (“microbiota”) present within the healthy lower airways [1–3].
Abstract
C. Rigauts和同事提供了有关气道共生的先前未认识的作用的见解Rothia Mucilaginosain attenuating proinflammatory responses toP. aeruginosa, an effect demonstrated consistently across a range of experimental modelshttps://bit.ly/3EIs9nv
Footnotes
Conflict of interest: R. Morton reports grants from Imperial College London (MRC Clinical Research Training Fellowship), outside the submitted work.
利益冲突:A。Singanayagam报告了医学研究委员会(临床科学家奖学金),英国抗微生物化疗学会(COVID-19 Grant)和英国医学协会(James Trust Research Grant)的赠款;来自阿斯利康的演讲酬金;在提交的工作之外。
Support statement: A. Singanayagam is supported by an MRC Clinician Scientist Fellowship. Funding information for this article has been deposited with theCrossref Funder Registry.
- 已收到2021年12月3日。
- AcceptedDecember 4, 2021.
- 复制right ©The authors 2022. For reproduction rights and permissions contactpermissions{at}ersnet.org