Extract
粘液异常在大多数(如果不是全部)疾病的发展和/或演变中起着重要作用。气道粘液既是气道防御刺激性和微生物的机械防御机制的关键组成部分,又是气道损伤的标志:其组成受到涉及急性和慢性气道疾病的各种病理生理机制的影响蛋白酶 - 抗蛋白酶不平衡。这些机制可以通过粘蛋白产生和/或离子传输途径的损伤诱导粘液组成异常,从而导致粘液水合[1]和/或通过其他成分的粘液中的整合,例如细胞外DNA和其他中性粒细胞粒细胞组成部分细胞外陷阱。
Abstract
The contribution of CFTR to the pathobiology of cigarette smoke-related chronic airway diseases deserves further investigationhttps://bit.ly/3FvP5Ym
脚注
Conflict of Interest: P-R. Burgel reports grants from Boehringer Ingelheim, GSK and Vertex; consulting fees and lecture honoraria from Boehringer Ingelheim, GSK, AstraZeneca, Vertex, Chiesi, Pfizer, Novartis, Zambon and Insmed; outside the submitted work. N. Roche reports grants from Boehringer Ingelheim, Novartis, GSK and Pfizer; consulting fees from Boehringer Ingelheim, GSK, AstraZeneca, Sanofi, Chiesi, Pfizer, Novartis and Teva; lecture honoraria from Boehringer Ingelheim, GSK, AstraZeneca, Sanofi, Chiesi, Pfizer, Novartis, Teva and Zambon; outside the submitted work.
- 已收到2022年4月29日。
- Accepted2022年4月30日。
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